This book covers the basic science of nuclear medicine along with health physics as relevant to nuclear medicine. This edition of the book is with some changes, from its first edition published in 2008. All the chapters have been thoroughly revised by the authors in the light of present knowledge on the subject. Few new chapters in dosimetry and PET/MRI have also been added. The book has 41 chapters, divided into six parts. The first part is devoted to basic atomic and nuclear physics, radioactivity, interaction of radiation, counting statistics, radiation detectors, in-vitro and in-vivo detection of radiation (planar and SPECT imaging with complete QC procedures), image filtering, image quality and Fourier transform. The second part is on dosimetry for internal emitters, dosimetry in radioiodine therapy, dosimetric considerations in Lutetium based targeted therapy, dosimetric aspects in radioembolisation with 90Y microspheres and 188Re-HDD-Lipiodol for HCC and dosimetry in diagnostic nuclear medicine using OLINDA/EXM software. The third part describes radionuclides used in medicine, radiopharmacy for diagnostic nuclear medicine (planer, SPECT and PET imaging) and their applications in clinical nuclear medicine. The fourth part is devoted to medical cyclotron, PET/CT (basic physics, instrumentation and performance evaluation), PET/CT technical aspects and image registration, correction techniques, applications of PET/CT in clinical nuclear medicine and in radiotherapy treatment planning, basic principles of CT and MR imaging. Introduction to PET/MRI and its clinical application are the two new chapters added in this edition. The fifth part includes some of the quantification techniques in nuclear medicine, such as background subtraction (in renography), deconvolution analysis and renal transit time parameters, and tracer kinetics. The sixth is on health physics which includes radiobiological concepts, radiobiological basis of radiological protection, ICRP recommendations, radiation safety in nuclear medicine and diagnostic reference levels. Students and teachers in nuclear medicine and allied sciences will find this book useful. Contents - Part - I Basic Physics and Imaging Techniques 1. Basic Atomic and Nuclear Physics - G.S. Pant and H. Rajabi 2. Interaction of Radiation with Matter - G.S. Pant 3. Radioactivity - G.S. Pant and A.K. Pandey 4. Counting Statistics - A.K. Pandey 5. Radiation Detectors - G.S. Pant 6. Radionuclide Dose Calibrator - G.S. Pant 7. Scintillation Detection (in vitro) - G.S. Pant 8. Radiation Detection in vivo and Gamma Camera Imaging - G.S. Pant 9. Single Photon Emission Tomography (SPECT) - G.S. Pant and H. Rajabi 10. Image Filtering in Nuclear Medicine - H. Rajabi and A.K. Pandey 11. Image Quality in Nuclear Medicine - G.S. Pant 12. Fourier Transform: Basic Concepts - H. Rajabi Part - II Dosimetry 13. Dosimetry of Internally Administered Radionuclides - A.R. Reddy 14. Radiation Dosimetry in Graves' Disease - G.S. Pant 15. Dosimetry with Iodine-131 in Differentiated Thyroid Cancer - Praveen Kumar and C.S. Bal 16. Dosimetric Considerations in Lutetium based Targeted Radionuclide Therapy - Ishita B. Sen and Parul Thakral 17. Dosimetric Aspects in Radioembolisation with 90Y Microspheres and 188Re-HDD-Lipiodol for Hepatocellular Carcinoma (HCC) - G.S. Pant and Ajay Kumar 18. Dose Estimation in Diagnostic Nuclear Medicine Procedures using OLINDA/EXM Personal Computer Code - Aruna Kaushik Part - III Radionuclides and Radiopharmaceuticals in Nuclear Medicine 19. Radionuclides in Medicine and Research - N. Ramamoorthy and Meera Venkatesh 20. Radiopharmaceuticals in Clinical Nuclear Medicine - M.G.R. Rajan 21. PET Radiochemistry and PET Radiopharmaceuticals - M.G.R. Rajan 22. Applications of Radionuclides in Clinical Nuclear Medicine - Girish K. Parida, Chetan D. Patel and C.S. Bal Part - IV Cyclotron, PET/CT and PET/MR 23. Medical Cyclotron: Basic Principle and Operation - G.S. Pant and S. Senthamizhchelvan 24. PET/CT: Physical Principles, Instrumentation and Performance Evaluation - G.S. Pant 25. Combined PET/CT: Technical Aspects and Image Registration - Habib Zaidi 26. Image Correction Techniques in SPECT and PET - Habib Zaidi 27. Computed Tomography in PET/CT - Mahadevappa Mahesh, Devasenathipathy Kandasamy and Raju Sharma 28. Clinical Applications of PET and PET-CT - Girish K. Parida and Rakesh Kumar 29. PET Imaging: Potential Applications in Gene and Stem Cell Therapy - Tarun Singhal 30. PET-CT Based Radiotherapy Treatment Planning - T. Ganesh, S. Agrawal and R. Prabhakar 31 MR Imaging – Basic Concepts - S. Senthil Kumaran 32. Basic Introduction to PET/MRI - S. Senthamizhchelvan and G.S Pant 33. Clinical Applications of PET/MRI - Amarnath Jena Part - V Quantification Techniques in Nuclear Medicine 34. Background Subtraction in Nuclear Medicine - H. Rajabi and G.S. Pant 35. Deconvolution Analysis and Renal Transit Time Parameters - H. Rajabi and G.S. Pant 36. Radiotracer Kinetics: Applications in Nuclear Medicine - Bharathi D. Jagadeesan Part - VI Health Physics and Radiation Safety 37. Basics of Radiobiology - G.S. Pant 38. Radiobiological Basis of Radiation Protection - B.S. Rao 39. ICRP Recommendations - A.R. Reddy and S.C. Jain 40. Radiation Safety in Nuclear Medicine - G.S. Pant and B. Rajashekhar Rao 41. Diagnostic Reference Levels for Nuclear Medicine - S.C. Jain and A.R. Reddy Annexures