Musical Excellence of Mridangam is an outcome and a rare fusion of art and science of an ancient South Indian instrument. Presented in two parts, the first part of the monograph, presented in conversation mode, shares some concepts on Musial Excellence and lays a foundation for research on musical instruments. The second part presents some original findings for further research. The book is an outcome of research and development on standardisation of fabrication, tonal characterisation and new innovations in design of the percussion instrument. This is one of the early examples of research and science for an Indian musical instrument. It presents a hypothesis. The tonic note, Dheem, observed at the Rishabham region seems the fundamental of an odd harmonic series. Clever juxtaposing of odd and even set of harmonic sequence of frequencies seems the signature of Mridangam. This monograph is a tribute to an ancient civilization that extolled musical excellence through ingenious methods of making and tuning.