‘Re- Imagining Indigenous Medical Traditions in Travancore’ is a research endeavour to comprehend and map the fundamental premises on which the Indian system of Medicine was anchored. The Indian System of Medicine had been all encompassing and Universal in its philosophical precepts and practices not withstanding its regional particularities. The myriad facets of the discipline have transcended boundaries of geography and human intellect weaving a syncretic and synthetic tapestry of medical knowledge and service. The Kerala medical tradition that forms an integral part of the larger Indian medical lore has centuries of unbroken continuity. The totality of Kerala’s indigenous medical tradition is an amalgamation of medical wisdom underscored by an intimate interaction with Ashtavaidya, Aryavaidya, Folk, Tribal, etc.,consummating in a novel synthesis. These medical traditions functioned in Travancore as an interconnected and mutually complementing system of knowledge. The research effort re- imagining the germane theme moves on to conceptualize the process of evolution of a synthesized product of indigenous medicine in Kerala with particular reference to Travancore.