The South Asian region has more relevance in COVID times as severe challenges in the countries require a solution. Analytical studies have given a broad perspective regarding South Asia as a region. It is socially constructed based on geographical barriers, but Myanmar and Afghanistan were not considered a part of it. While analysing the importance, the editor has deliberated that multilateralism in the South Asian region can be the greatest hope for actionable policies if adequately monitored and complied with in full. There are two dimensions of International Politics; the first is Positive and Creative, and the second is Reality. Geopolitics has entered everywhere, and we have to look at the whole world and how Realism has shaped South Asia. There has been a question on capitalist growth and opportunities for the world. The pandemic has given a blow to multilateralism. Sometimes, an introverted economy can lead to fewer economic developments. There has been an aggressive rise of nationalism amongst Indians towards neighbours. Unless we work together and as a team, we cannot overcome this pandemic, as an introverted economy will not take any country anywhere. South Asia has Cold War flavours shaped in the 20th century. India needs to emphasise its policies while Afghanistan and Thailand have not flourished in the South Asian region compared to the whole world. The editor has taken up various aspects, namely, ASEAN outlook on the Indo-Pacific narrative, India`s relations with Africa, China`s strategic gameplay in the region, India`s energy diplomacy towards South Asian countries, ISIS operations in South Asia, Bilateral relations, among South Asian nations, Multilateralism in Nepal`s foreign policy and Transformation of Sino-India relations in South Asia, especially in the COVID-19 era. Some ideas of future prospects can be gleaned from this book. The editor is confident that this book will inform readers and researchers about the nuances of global challenges like the pandemic, terrorism, and climate change and the ensuing opportunities for collaboration. The new global order continues to unfold for a multilateral governance effort and pinpoints many undercurrents in Asia and Asia-Pacific.