The epidemic of substance abuse in adolescents is increasing at an alarming rate in India and this is the direct result of the changing cultural values, fierce competition in the fields of education and employment, growing economic burden on families and declining supportive bonds for adolescents in this transitional age. The impact of substance abuse among adolescents witnesses their first experimentation towards various drugs, especially those that are easily available including glues, tobacco, cannabis and alcohol. Amongst adolescents, the highest at-risk population include street children, child labourers and teens who have a family history of drug abuse and other emotional and behavioural challenges at home. Consequences of substance abuse also include quarrels with friends, family or relatives, as well as accidents and severe health disorders, with some also dropped out of school due to poor performance in the academic.