The Principles and Practice of Medicine, authored by Sir William Osler and later revised by Thomas McCrae, is a landmark medical textbook first published in 1892. Known as a foundational work in clinical medicine, it covers a wide range of diseases, diagnostic techniques, and treatments. Osler’s approach emphasizes bedside learning, integrating clinical observations with pathological findings. The book's detailed descriptions and emphasis on patient-centered care influenced generations of doctors and medical students, shaping modern internal medicine. McCrae’s contributions in later editions added contemporary updates, ensuring its continued relevance as a comprehensive resource for medical practitioners. ABOUT THE AUTHOR Sir William Osler (1849–1919) was a Canadian physician and founding professor of Johns Hopkins Hospital, widely regarded as the "Father of Modern Medicine." He established the first residency program for specialty training, revolutionizing medical education. Osler was also an author, historian, and co-founder of medical libraries, including McGill's Osler Library. Thomas McCrae (1870–1935), a Canadian professor at Jefferson Medical College, was a student and colleague of Sir William Osler. Known for his quote "more is missed by not looking than not knowing," he co-edited The Principles and Practice of Medicine.